Friday, November 21, 2008

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How were the names of the molecules

The names of the molecules are curious ...
I have always wondered what they meant ... For example, in monoclonal antibodies, where the "tail" may be ZUMAB or XIMAB.
I already knew the names of the molecules are composed of one part fantasy, and part of which refers to the class / function, so thanks to Google, I have taken the plunge: ...

ZUMAB is a new word, a combination that indicates that we are faced with a humanized monoclonal antibody. The class is opposed to
XIMAB, which are chimeric monoclonal antibodies.

All monoclonal antibodies are born from the meeting of specific antibody developed in mice and mouse myeloma cells (myeloma cells is used because it is a tumor replicates madly in practice is the yeast antibody). The difference between the two is that the chimeric still retain much of the genetic structure of mice, so that the human body tends to react and produce antibodies for antibodies ... humanized versions instead steal some of this genetic mouse antibody, and then make it more "acceptable" to the human body.
If you rodesse increasingly curiosity, I suggest a very interesting presentation, here.

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